Pathways
Telomere Extension in Yeast
Description:
Telomeres are specialized nucleoprotein structures found at the ends of linear eukaryotic chromosomes. Telomeres confer stability to chromosomes by preventing nucleolytic degradation and recombination. They also function in chromosomal localization, nuclear architecture, and repression of nearby genes. The telomeric DNA of most organisms consists of simple tandem repeats that are rich in dG and dT residues on the 3' end-containing strand. This strand is synthesized by a ribonucleoprotein complex called telomerase, an enzy...
References:
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Identification and characterization of a telomerase activity from Schizosaccharomyces pombe.
Nucleic Acids Res. 1997 Nov 1; 25(21): 4331-7. -
Involvement of replicative polymerases, Tel1p, Mec1p, Cdc13p, and the Ku complex in telomere-telomere recombination.
Mol Cell Biol. 2002 Aug; 22(16): 5679-87. -
Positive and negative regulation of telomerase access to the telomere.
J Cell Sci. 2000 Oct; 113 Pt 19:3357-64. Review. -
Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast.
Cell. 1999 May 28; 97(5): 621-33.
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