Pathways
TH17 Pathway
Description:
T cells acts as a workhorse for the adaptive immune system, with the job of orchestrating defences against microbial invasion. A subcategory of T cells, T helper cells, defends against microbes, also causes trouble by inducing inflammation in immune-mediated diseases. T helper cells become further specialized, or differentiated, and a type known as TH17 has recently stepped into the limelight. These cells produce a messenger molecule called IL-17 (Interleukin-17), and are notable both in providing defence against extracellular b...
References:
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Control of adaptive immunity by the innate immune system.
Nat Immunol. 2015 Apr;16(4):343-53. doi: 10.1038/ni.3123. Review. -
Th17 cells in autoimmune and infectious diseases.
Int J Inflam. 2014;2014:651503. doi: 10.1155/2014/651503. Epub 2014 Aug 3. Review. -
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases.
Cytokine. 2015 Jul;74(1):5-17. doi: 10.1016/j.cyto.2014.09.011. Epub 2014 Oct 30. Review. -
The 3 major types of innate and adaptive cell-mediated effector immunity.
J Allergy Clin Immunol. 2015 Mar;135(3):626-35. doi: 10.1016/j.jaci.2014.11.001. Epub 2014 Dec 18. Review.
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