Pathways
Thalassemia
Description:
Thalassemia is one of the most deadly inherited blood disorders, characterized by abnormal production of hemoglobin and excessive destruction of red blood cells. It is a single-gene disorder that is passed from parents to child by autosomal recessive pattern of inheritance. Progressive iron overload and Anemia are the most salient and ultimately fatal complications of Thalassemia. According to the type of globin polypeptide chain that is underproduced, Thalassemia is generally classified into 3 major types: Alpha, Beta and ...
References:
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Classification of the disorders of hemoglobin.
Cold Spring Harb Perspect Med. 2013 Feb 1;3(2):a011684. -
Regulation of human alpha-globin gene expression and alpha-thalassemia.
Genet Mol Res. 2008 Oct 14;7(4):1045-53. -
Controlling alpha-globin: a review of alpha-globin expression and its impact on beta-thalassemia.
Haematologica. 2008 Dec;93(12):1868-76. Epub 2008 Sep 2. -
The Alpha Thalassaemias.
Cell Mol Life Sci. 2008 Nov 17.
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