Pathways
The Canonical OAS RNaseL Pathway
Description:
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Cellular innate immune system represents the first line of defense against invading pathogens. To counter virus infection, the immune system produces antiviral cytokines. Interferon (IFN) is the most powerful antiviral cytokine, and it induces IFN-stimulated genes that mediate antiviral effector functions. Among the proteins induced by IFN, the oligoadenylate synthase (OAS) proteins have been identified as enzymes that sen...
References:
-
Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases.
Exp Mol Med. 2015 Mar 6;47(3):e144. doi: 10.1038/emm.2014.110. -
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.
Nat Rev Immunol. 2014 Aug;14(8):521-8. doi: 10.1038/nri3719. Epub 2014 Jul 18. -
RNase L and the NLRP3-inflammasome: An old merchant in a new trade.
Cytokine Growth Factor Rev. 2016 Jun;29:63-70. doi: 10.1016/j.cytogfr.2016.02.008. Epub 2016 Mar 10. -
Innate immunity to influenza virus infection.
Nat Rev Immunol. 2014 May;14(5):315-28. doi: 10.1038/nri3665.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions