Pathways
The Salvage Pathway from Serine to Phosphatidylcholine
Description:
Phosphatidylserine (or 1, 2-Diacyl-sn-Glycero-3-Phospho-L-Serine) is the only amino acid-containing glycerophospholipid in animal cells. Although it is distributed widely among animals, plants and microorganisms, it is usually less than 10% of the total phospholipids, the greatest concentration being in myelin from brain tissue. It is an acidic (anionic) phospholipid with three ionizable groups, i.e. the phosphate moiety, the amino group and the carboxyl function. As with other acidic lipids, it exists in nature in salt form....
References:
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The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine.
IUBMB Life. 2010 Jun;62(6):414-28. doi: 10.1002/iub.337. -
Phosphatidylserine in the brain: metabolism and function.
Prog Lipid Res. 2014 Oct;56:1-18. doi: 10.1016/j.plipres.2014.06.002. Epub 2014 Jun 30. -
Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells.
Biochim Biophys Acta. 2013 Mar;1831(3):543-54. doi: 10.1016/j.bbalip.2012.08.016. Epub 2012 Aug 29. -
The transition of prothrombin to thrombin.
J Thromb Haemost. 2013 Jun;11 Suppl 1(0 1):265-76. doi: 10.1111/jth.12217.
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