Pathways
Thrombin Signaling
Description:
Thrombin is a multifunctional serine protease involved in a number of pathophysiological processes that include blood clotting, inflammation, repair processes and tumor metastasis. In brain, thrombin regulates the viability of neurons and astrocytes by increasing survival under conditions of hypoglycemia and oxidative stress and inducing apoptosis under other conditions. Thrombin is also chemotactic for macrophages and mitogenic for smooth muscle cells, fibroblasts, and astrocytes and induces secretion of growth factors and cyto...
References:
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Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond.
J Mol Med (Berl). 2013 Nov;91(11):1257-71. doi: 10.1007/s00109-013-1074-5. Epub 2013 Aug 17. Review. -
Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits β-arrestin-mediated endosomal signaling.
J Biol Chem. 2013 Apr 19;288(16):11203-15. doi: 10.1074/jbc.M112.439950. Epub 2013 Mar 8. -
Turning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug development.
J Biol Chem. 2012 Apr 13;287(16):12787-96. doi: 10.1074/jbc.R112.355461. Epub 2012 Feb 28. Review. -
Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis.
J Cell Mol Med. 2015 Jun;19(6):1346-56. doi: 10.1111/jcmm.12520. Epub 2015 Feb 16.
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