Pathways
Thrombopoietin Pathway
Description:
Throughout adult life, all blood cells are constantly regenerated from a small pool of hematopoietic stem cells. A single purified stem cell injected into a lethally irradiated host is sufficient to reconstitute all lineages, demonstrating pluripotency and an enormous regenerative potential. Genes encoding secreted growth factors, signal transduction molecules and nuclear proteins regulate this process. The helical cytokine family comprises structurally related secreted proteins that play an important role as hematopoietic gr...
References:
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The biology of thrombopoietin and thrombopoietin receptor agonists.
Int J Hematol. 2013 Jul;98(1):10-23. doi: 10.1007/s12185-013-1382-0. Epub 2013 Jul 3. -
Thrombopoietin and hematopoietic stem cells.
Cell Cycle. 2011 May 15;10(10):1582-9. doi: 10.4161/cc.10.10.15619. Epub 2011 May 15. -
The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin.
Front Endocrinol (Lausanne). 2017 Mar 31;8:59. doi: 10.3389/fendo.2017.00059. -
Chemotherapy-induced thrombocytopenia derives from the selective death of megakaryocyte progenitors and can be rescued by stem cell factor.
Cancer Res. 2007 May 15;67(10):4767-73. doi: 10.1158/0008-5472.CAN-06-4303.
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