TNF-Induced Apoptosis Implicating Sphingolipids

Description:

Various lipid molecules serve as second messengers for transducing signals from the cell surface to the cell interior and trigger specific cellular responses. Recently, several sphingolipids have emerged as cellular constituents that are able to promote, mediate or counterbalance apoptosis. Sphingolipids are a family of membrane lipids whose structure is made up of a long-chain sphingoid base backbone (such as sphingosine), an amide-linked fatty acid of varying chain and one of various polar head groups (hydroxyl for ceramide, p...

References:

Abnormal Sphingolipid World in Inflammation Specific for Lysosomal Storage Diseases and Skin Disorders.
Moskot M, Bocheńska K, Jakóbkiewicz-Banecka J, Banecki B, Gabig-Cimińska M.
Int J Mol Sci. 2018 Jan 15;19(1). pii: E247. doi: 10.3390/ijms19010247. Review.
Membrane trafficking of death receptors: implications on signalling.
Schneider-Brachert W, Heigl U, Ehrenschwender M.
Int J Mol Sci. 2013 Jul 11;14(7):14475-503. doi: 10.3390/ijms140714475. Review.
Ceramide in the molecular mechanisms of neuronal cell death. The role of sphingosine-1-phosphate.
Czubowicz K, Strosznajder R.
Mol Neurobiol. 2014 Aug;50(1):26-37. doi: 10.1007/s12035-013-8606-4. Epub 2014 Jan 14.
Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System.
Cannavo A, Liccardo D, Komici K, Corbi G, de Lucia C, Femminella GD, Elia A, Bencivenga L, Ferrara N, Koch WJ, Paolocci N, Rengo G.
Front Pharmacol. 2017 Aug 23;8:556. doi: 10.3389/fphar.2017.00556. eCollection 2017. Review.

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Pathways

TNF-Induced Apoptosis Implicating Sphingolipids

Description:

References:

Abnormal Sphingolipid World in Inflammation Specific for Lysosomal Storage Diseases and Skin Disorders.

Membrane trafficking of death receptors: implications on signalling.

Ceramide in the molecular mechanisms of neuronal cell death. The role of sphingosine-1-phosphate.

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System.

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TNF-Induced Apoptosis Implicating Sphingolipids

Description:

References:

Abnormal Sphingolipid World in Inflammation Specific for Lysosomal Storage Diseases and Skin Disorders.

Membrane trafficking of death receptors: implications on signalling.

Ceramide in the molecular mechanisms of neuronal cell death. The role of sphingosine-1-phosphate.

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System.

Databases

Tools

Institutional License

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