Pathways
TNF Signaling
Description:
Tumor necrosis factor (TNF) is a pro-inflammatory cytokine with the capacity to induce apoptosis. It is enriched in the tumor microenvironment, promotes tumor growth and subverts innate immune responses to cancer cells. TNF is the best studied member of the TNF superfamily. TNF-alpha can bind to two related receptors, TNF receptors 1 and 2 (TNFR1 and TNFR2), which are also used by other, similar ligands. By binding to TNFR1 and TNFR2, TNF activates distinct signaling pathways important for cell proliferation, cell death and i...
References:
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Looking beyond death: a morphogenetic role for the TNF signalling pathway.
J Cell Sci. 2009 Jun 15;122(Pt 12):1939-46. doi: 10.1242/jcs.044487. Review. -
TNF signaling drives myeloid-derived suppressor cell accumulation.
J Clin Invest. 2012 Nov;122(11):4094-104. doi: 10.1172/JCI64115. Epub 2012 Oct 15. -
Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.
J Cell Sci. 2015 Feb 15;128(4):656-69. doi: 10.1242/jcs.149385. Epub 2015 Jan 20. -
TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
Genes Dev. 2011 Oct 1;25(19):2069-78. doi: 10.1101/gad.17224711.
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