Pathways
TNF Superfamily Pathway
Description:
Tumor necrosis factor (TNF) superfamily proteins consisting of 19 members and 29 receptors regulate cell proliferation, cell death, and morphogenesis. The tumor necrosis factor superfamilies members provide key communication signals between various cell types during development, especially in the skin, bones, and lymphoid organs, and maintain organ homeostasis and initiate tissue responses. Because of these essential roles, TNFRSFs and the TNF superfamily (TNFSF) ligands are attractive targets for treating diverse diseases, s...
References:
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Structural principles of tumor necrosis factor superfamily signaling.
Sci Signal. 2018 Jan 2;11(511). pii: eaao4910. doi: 10.1126/scisignal.aao4910. Review. -
Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey.
Blood. 2012 Jan 19;119(3):651-65. doi: 10.1182/blood-2011-04-325225. Epub 2011 Nov 3. Review. -
The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses.
Immunity. 2016 May 17;44(5):1005-19. doi: 10.1016/j.immuni.2016.04.019. Review. -
Looking beyond death: a morphogenetic role for the TNF signalling pathway.
J Cell Sci. 2009 Jun 15;122(Pt 12):1939-46.
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