TOB in T-Cell Signaling

Description:

Efficient ligation of the TCR (T-Cell Receptor) by high-density Antigen can generate a productive T-Cell response and result in cytokine secretion and clonal expansion that is crucial for an optimal immune response. TCR stimulation may provoke different cell responses (proliferation, anergy to subsequent stimuli, cell death) in mature circulating T-Cells (Ref.1). Deregulation of T-Cell function, whether by defect or by excess, may result in dire consequences for us i.e., immunodeficiency and autoimmunity respectively. If the ...

References:

New insights into the molecular basis of T cell anergy: anergy factors, avoidance sensors, and epigenetic imprinting.
Wells AD.
J Immunol. 2009 Jun 15;182(12):7331-41. doi: 10.4049/jimmunol.0803917.
T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.
Tu E, Chia CPZ, Chen W, Zhang D, Park SA, Jin W, Wang D, Alegre ML, Zhang YE, Sun L, Chen W.
Immunity. 2018 Apr 17;48(4):745-759.e6. doi: 10.1016/j.immuni.2018.03.025.
Molecular mechanisms of T-cell tolerance.
Nurieva RI, Liu X, Dong C.
Immunol Rev. 2011 May;241(1):133-44. doi: 10.1111/j.1600-065X.2011.01012.x.
The role of antiproliferative gene Tob1 in the immune system.
Baranzini SE.
Clin Exp Neuroimmunol. 2014 Jun 1;5(2):132-136. doi: 10.1111/cen3.12125.

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TOB in T-Cell Signaling

Description:

References:

New insights into the molecular basis of T cell anergy: anergy factors, avoidance sensors, and epigenetic imprinting.

T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.

Molecular mechanisms of T-cell tolerance.

The role of antiproliferative gene Tob1 in the immune system.

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Tools

Institutional License

Pathways

TOB in T-Cell Signaling

Description:

References:

New insights into the molecular basis of T cell anergy: anergy factors, avoidance sensors, and epigenetic imprinting.

T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.

Molecular mechanisms of T-cell tolerance.

The role of antiproliferative gene Tob1 in the immune system.

Databases

Tools

Institutional License

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