Pathways
TOB in Osteoblast Signaling
Description:
TOB (Transducer of ErbB2), a member of the TOB and BTG (B-cell Translocation Gene) anti-proliferative protein family, negatively regulates the proliferation of Osteoblasts. Bone is formed and resorbed continuously, starting in the embryo and continuing throughout adult life. This process occurring in adult bone is called bone remodeling. Bone remodeling is accomplished by precise coordination of two cell types, Osteoblasts and Osteoclasts. Osteoblasts deposit calcified bone matrix, and Osteoclasts resorb it. Deregulation of b...
References:
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Tob, a member of the APRO family, regulates immunological quiescence and tumor suppression.
Cell Cycle. 2009 Apr 1; 8(7):1019-25. Epub 2009 Apr 30. Review. -
Bone remodelling at a glance.
J Cell Sci. 2011 Apr 1; 124(Pt 7):991-8. doi: 10.1242/jcs.063032. No abstract available. -
Modulating Bone Resorption and Bone Formation in Opposite Directions in the Treatment of Postmenopausal Osteoporosis.
Drugs. 2015 Jul; 75(10):1049-58. doi: 10.1007/s40265-015-0417-7. Review. -
Bmp Induces Osteoblast Differentiation through both Smad4 and mTORC1 Signaling.
Mol Cell Biol. 2017 Feb 1; 37(4). pii: e00253-16. doi: 10.1128/MCB.00253-16. Print 2017 Feb 15.
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