Toll-Like Receptors in COVID-19

Description:

COVID-19 is an infectious disease caused by a new coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has infected millions of people throughout the world leading to a global health crisis. COVID-19 declared as pandemic by World Health Organization, generally causes lung inflammation and pneumonia. In extreme cases, it can also cause injury to multiple organs including the lungs, cardiovascular system, liver, kidneys, muscles and brain. Serious patients generally exhibit a “cytokine stor...

References:

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation.
Aboudounya MM, Heads RJ.
Mediators Inflamm. 2021 Jan 14;2021:8874339. doi: 10.1155/2021/8874339.
COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis.
Sohn KM, Lee SG, Kim HJ, Cheon S, Jeong H, Lee J, Kim IS, Silwal P, Kim YJ, Paik S, Chung C, Park C, Kim YS, Jo EK.
J Korean Med Sci. 2020 Sep 28;35(38):e343. doi: 10.3346/jkms.2020.35.e343.
Toll-like receptors and COVID-19: a two-faced story with an exciting ending.
Onofrio L, Caraglia M, Facchini G, Margherita V, Placido S, Buonerba C.
Future Sci OA. 2020 Jul 30;6(8):FSO605. doi: 10.2144/fsoa-2020-0091.
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S.
Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.

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Pathways

Toll-Like Receptors in COVID-19

Description:

References:

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation.

COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis.

Toll-like receptors and COVID-19: a two-faced story with an exciting ending.

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.

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Toll-Like Receptors in COVID-19

Description:

References:

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation.

COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis.

Toll-like receptors and COVID-19: a two-faced story with an exciting ending.

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.

Databases

Tools

Institutional License

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