Pathways
Tooth Development and Decay
Description:
Teeth develop as ectodermal appendages in vertebrate embryos, and their early development resembles morphologically as well as molecularly other organs such as Hairs and Glands. Interactions between the Ectoderm and underlying Mesenchyme constitute a central mechanism regulating the morphogenesis of all these organs. Central features of Tooth morphogenesis are the formation of the Epithelial Placode, the budding of the Epithelium, the condensation of Mesenchyme around the bud, and the folding and growth of the Epitheli...
References:
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Signaling networks regulating tooth organogenesis and regeneration, and the specification of dental mesenchymal and epithelial cell lineages.
Cold Spring Harb Perspect Biol. 2012 Apr 1;4(4):a008425. -
Dental enamel formation and implications for oral health and disease.
Physiol Rev. 2017 Jul 1;97(3):939-993. doi: 10.1152/physrev.00030.2016. -
Extracellular phosphate alters cementoblast gene expression.
J Dent Res. 2006 Jun;85(6):505-9. -
Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape.
J Biol Chem. 2006 Feb 24;281(8):5008-16. Epub 2005 Dec 19.
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