Pathways
TOR Complexes in Yeast
Description:
TOR (Target of Rapamycin) is a PIKK (Phosphatidylinositol Kinase-related protein Kinase) that controls cell growth and proliferation. In all eukaryotic cells expressing the protein, TOR function is controlled by nutrient availability, which ensures that protein synthesis is repressed when the supply of precursor amino acids is insufficient. In mammalian cells, one branch of this pathway controls general translational initiation, whereas a separate branch specifically regulates the translation of r-protein (ribosomal protein) ...
References:
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The TOR signaling cascade regulates gene expression in response to nutrients.
Genes Dev. 1999 Dec 15; 13(24):3271-9. -
TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.
Mol Cell. 2001 Nov; 8(5):1017-26. -
RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p.
EMBO J. 2001 Dec 17; 20(24):7209-19. -
The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine.
Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6784-9. Epub 2002 May 07.
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