Pathways
TRAIL Pathway
Description:
TRAIL (TNF-Related Apoptosis-Inducing Ligand) is a protein consisting of 281 amino acids. It is also called Apo2L. Five proteins, TRAILR1 (DR4), TRAILR2 (DR5/ TRICK2 or KILLER), TRAILR3 (DcR1/ TRID or LIT), TRAILR4 (DcR2 or TRUNDD), and Opg (Osteoprotegerin), have been identified as TRAIL receptors. Both TRAILR1 and TRAILR2 contain the functional DD (Death Domain), capable of inducing apoptosis. The other three receptors DcR1, DcR2 and Opg serve as "decoy" receptors. These three receptors can bind to TRAIL, but ca...
References:
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TRAIL blazing Strategies for Cancer Treatment.
Cancers (Basel). 2019 Mar 30;11(4):456. doi: 10.3390/cancers11040456. -
Death Receptors: New Opportunities in Cancer Therapy.
Acta Naturae. 2017 Jul-Sep;9(3):55-63. -
Regulation of the human TRAIL gene. Cancer Biol Ther.
Cancer biology & therapy. 2012 Oct 1;13(12):1143-51. -
Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy.
Experimental Biology and Medicine. 2015 Jun;240(6):760-73.
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