Pathways
Transcription of tRNA
Description:
Transfer RNA (tRNA) is a small RNA chain (74-93 nucleotides) that converts information contained in mRNA into amino acid sequence. tRNA synthesis involves several steps, including initial transcript synthesis, tRNA precursors maturation and amino acid mediated charging of tRNA molecules. Maturation and charging of tRNA occurs both in cytoplasm as well as nucleus. In all organisms, tRNAs are transcribed in a pre-tRNA form that requires multiple processing steps before the mature tRNA is ready for use in translation (Ref.1).
References:
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Regulation of tRNA synthesis and modification in physiological conditions and disease.
Biochim Biophys Acta Gene Regul Mech. 2018 Apr;1861(4):283-284. doi: 10.1016/j.bbagrm.2018.03.004. Epub 2018 Mar 16. -
Structural rearrangements of the RNA polymerase III machinery during tRNA transcription initiation.
Biochim Biophys Acta Gene Regul Mech. 2018 Apr;1861(4):285-294. doi: 10.1016/j.bbagrm.2017.11.005. Epub 2017 Nov 15. -
Mitochondrial tRNAs as light strand replication origins: similarity between anticodon loops and the loop of the light strand replication origin predicts initiation of DNA replication.
Biosystems. 2010 Feb;99(2):85-93. doi: 10.1016/j.biosystems.2009.09.003. Epub 2009 Sep 13. -
“tRNA Processing and Subcellular Trafficking Proteins Multitask in Pathways for Other RNAs.”
Frontiers in genetics vol. 10 96. 20 Feb. 2019, doi:10.3389/fgene.2019.00096
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