Pathways
Transcriptional Regulatory Network in Embryonic Stem Cell
Description:
Stem Cells are undifferentiated cells that can give rise to several lineages of differentiated cell types. They are the founder cells for every organ, tissue and cell in the body. Stem cells are characterized by the ability to self-renew and maintain Pluripotency. These features allow Stem Cells to fulfill their multiple functions, namely to provide enough cells during organogenesis, to control tissue homeostasis and, in addition, to ensure regeneration and repair. ESCs (Embryonic Stem Cells) are derived from the ICM (Inner Cell...
References:
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Concise review: pursuing self-renewal and pluripotency with the stem cell factor Nanog.
Stem Cells. 2013 Jul;31(7):1227-36. doi: 10.1002/stem.1384. Review. -
Totipotency and lineage segregation in the human embryo.
Mol Hum Reprod. 2014 Jul;20(7):599-618. doi: 10.1093/molehr/gau027. Epub 2014 Apr 3. Review. -
From blastocyst to gastrula: gene regulatory networks of embryonic stem cells and early mouse embryogenesis.
Philos Trans R Soc Lond B Biol Sci. 2014 Dec 5;369(1657). pii: 20130542. doi: 10.1098/rstb.2013.0542. Review. -
Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas.
Cell Stem Cell. 2016 Jan 7;18(1):118-33. doi: 10.1016/j.stem.2015.09.010.
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