Pathways
Tregs in Tumor Escape Checkpoints
Description:
Specific T cell populations have suppressive/regulatory cells known as Regulatory T-cell or Tregs (Previously known as suppressor T-cell). Among them CD4+ regulatory T cells (Tregs) basically has two different subsets Tr1 and Th3 cells which are differentiated by their distinct suppressive mechanisms. The thymus-derived Tregs or natural Tregs (nTregs) express CD4 and high CD25 with FOXP3 (Forkhead Box-P3) to be a key regulatory gene. Apart from these, other markers of Treg include CTLA4 (Cytotoxic T-Lymphocyte-Associated prot...
References:
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Tregs: Where We Are and What Comes Next?
Front Immunol. 2017 Nov 24;8:1578. doi: 10.3389/fimmu.2017.01578. -
The Role of Natural Killer T Cells in Cancer-A Phenotypical and Functional Approach.
Front Immunol. 2018 Feb 27;9:367. doi: 10.3389/fimmu.2018.00367. -
Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells.
Oncoimmunology. 2015 Apr 1;4(7):e1016700. doi: 10.1080/2162402X.2015.1016700. -
The role of STAT3 in leading the crosstalk between human cancers and the immune system.
Cancer Lett. 2018 Feb 28;415:117-128. doi: 10.1016/j.canlet.2017.12.003. Epub 2017 Dec 6.
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