Pathways
TREM1 Pathway
Description:
TREMs (Triggering Receptor Expressed on Myeloid Cells) are a family of recently discovered receptors of the immunoglobulin superfamily, expressed on various cells of the myeloid lineage, which play important roles in innate immune responses, such as to activate inflammatory responses and to contribute to septic shock in response to microbial-mediated infections (Ref.1). During the onset of an infection, the host must launch a rapid innate response to control pathogen proliferation and spread the same until the adaptive resp...
References:
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Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies.
J Immunol Res. 2019 Apr 14 -
Triggering receptor expressed on myeloid cells type 1 as a potential therapeutic target in sepsis.
Dimens Crit Care Nurs. 2012 Jan-Feb;31(1):1-6. -
Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia.
N Engl J Med. 2004 Jan 29;350(5):451-8. -
Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival.
J Immunol. 2004 Apr 15;172(8):4956-63.
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