Pathways
Tumoricidal Effects of Hepatic NK Cells
Description:
The liver is a major site for the formation and metastasis of Tumors. Malignant Liver Tumors fall into two types: Primary and Metastatic. While Primary Liver tumors such as HCC (Hepatocellular Carcinoma) originate in the liver itself, Metastatic or Secondary Liver Tumors commpnly known as “Liver Metastases” are cancerous tumors that originate at sites remote from the liver and spread to the liver via the bloodstream. As filtration of blood is one of the main functions of Liver, cancer cells from other parts of the body have ...
References:
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Application of tissue-specific NK and NKT cell activity for tumor immunotherapy.
J Autoimmun. 2009 Nov-Dec;33(3-4):275-81. -
Regulation of NK cell repertoire and function in the liver.
Crit Rev Immunol. 2011;31(1):43-52. -
Host-microbe interactions and defense mechanisms in the development of amoebic liver abscesses.
Clin Microbiol Rev. 2009 Jan;22(1):65-75, Table of Contents. -
Tethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarization.
J Immunol. 2010 Sep 1;185(5):2918-26.
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