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Pathways

Type-1 Diabetes Mellitus

Description:

Type 1 diabetes, formerly termed IDDM (Insulin-Dependent Diabetes Mellitus), is a chronic organ-specific autoimmune disorder caused by proinflammatory autoreactive CD4+ and CD8+ T cells, which mediate progressive and selective damage of insulin producing pancreatic beta-cells. The reduction of beta-cell mass leads to a lack of insulin and thereby loss of blood glucose control. To date, it has not been possible to prevent the au[...]

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