Pathways
Type-1 Diabetes Mellitus
Description:
Type 1 diabetes, formerly termed IDDM (Insulin-Dependent Diabetes Mellitus), is a chronic organ-specific autoimmune disorder caused by proinflammatory autoreactive CD4+ and CD8+ T cells, which mediate progressive and selective damage of insulin producing pancreatic beta-cells. The reduction of beta-cell mass leads to a lack of insulin and thereby loss of blood glucose control. To date, it has not been possible to prevent the autoimmune response to beta-cells in human, due probably to its unknown aetiology, although it is know...
References:
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Immunotherapeutic treatment of autoimmune diabetes.
Crit Rev Immunol. 2013;33(3):245-81 -
Type 1 diabetes mellitus and pregnancy
Rev Obstet Gynecol. 2010 Summer;3(3):92-100 -
Environmental factors in the development of Type 1 diabetes.
Rev Endocr Metab Disord. 2006 Sep;7(3):149-62 -
Environmental triggers of type 1 diabetes.
Cold Spring Harb Perspect Med. 2012 Jul;2(7):a007690. doi: 10.1101/cshperspect.a007690
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