Pathways
Ubiquitin-Proteasome Dependent Proteolysis
Description:
The Proper functioning of a cell requires careful control of the levels of important structural proteins, enzymes, and regulatory proteins. Protein molecules are continuously synthesised and degraded in all living organisms. The concentration of individual cellular proteins is determined by a balance between the rates of synthesis and degradation, which in turn are controlled by a series of regulated biochemical mechanisms. Differences in the rates of protein synthesis and breakdown result in cellular and tissue atrophy (loss...
References:
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Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract.
Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1071-6. doi: 10.1073/pnas.1404059112. Epub 2015 Jan 12. Erratum in: Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E817. Jian, Shuhong [corrected to Jiang, Shuhong]. -
Ubiquitin-Like Proteasome System Represents a Eukaryotic-Like Pathway for Targeted Proteolysis in Archaea.
MBio. 2016 May 17;7(3). pii: e00379-16. doi: 10.1128/mBio.00379-16. Erratum in: MBio. 2016;7(4). pii: e01192-16. doi: 10.1128/mBio.01192-16. -
Relationship between the proteasomal system and autophagy.
Int J Biochem Mol Biol. 2013 Mar 31;4(1):1-26. Print 2013. -
The complexity of recognition of ubiquitinated substrates by the 26S proteasome.
Biochim Biophys Acta. 2014 Jan;1843(1):86-96. doi: 10.1016/j.bbamcr.2013.07.007. Epub 2013 Jul 18. Review.
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