Pathways
UVA-Induced MAPK Signaling
Description:
Ultraviolet radiation (UVR) is an electromagnetic radiation that is shorter in wavelength than visible light but longer than X-rays. It falls in the range of 100nm to 400nm and is the most important environmental carcinogen leading to the development of skin cancers. UVR is divided into at least three different categories based on wavelength that includes ultraviolet C (UVC; 100–280 nm), ultraviolet B (UVB; 280–320 nm) and ultraviolet A (UVA; 320–400nm). 90-95% of terrestrial radiation from the m...
References:
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Roles of UVA radiation and DNA damage responses in melanoma pathogenesis.
Environ Mol Mutagen. 2018 Jun;59(5):438-460. doi: 10.1002/em.22176. Epub 2018 Feb 21. -
Protein kinases and transcription factors activation in response to UV-radiation of skin: implications for carcinogenesis.
Int J Mol Sci. 2012;13(1):142-72. doi: 10.3390/ijms13010142. Epub 2011 Dec 23. -
Activation of p38 MAP kinase and JNK pathways by UVA irradiation.
Photochem Photobiol Sci. 2012 Jan;11(1):54-61. doi: 10.1039/c1pp05133d. Epub 2011 Aug 22.pub 2001 Jan 31. -
EGFR activation and ultraviolet light-induced skin carcinogenesis.
J Biomed Biotechnol. 2007;2007(3):97939. doi: 10.1155/2007/97939. Epub 2007 Apr 23.
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