Pathways
VAV Signaling in T-Lymphocyte
Description:
VAV(Oncogene Vav) family of proteins act as GEFs (Guanine Nucleotide Exchange Factors) and activators of Rho family GTPases, and are known to orchestrate cytoskeletal changes and cell migration in response to extracellular stimuli by catalyzing the exchange of GDP for GTP. Of the three mammalian isoforms, Vav1 is primarily expressed in hematopoietic cells, while Vav2 and Vav3 are more ubiquitously expressed. VAV proteins are found in the cytoplasm...
References:
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The Vav GEF Family: An Evolutionary and Functional Perspective.
Cells. 2019 May 16;8(5):465. doi: 10.3390/cells8050465. -
Vav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28.
J Proteome Res. 2015 Jul 2;14(7):2963-75. doi: 10.1021/acs.jproteome.5b00340. Epub 2015 Jun 16. -
Viral modulation of T-cell receptor signaling.
J Virol. 2008 May;82(9):4194-204. doi: 10.1128/JVI.00059-08. Epub 2008 Feb 20. -
An unexpected tumor suppressor role for VAV1a.
Mol Cell Oncol. 2018 Feb 23;5(3):e1432257. doi: 10.1080/23723556.2018.1432257.
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