Pathways
VEGF Family Ligands and Receptor Interactions
Description:
Angiogenesis and lymphangiogenesis, the growth of new blood vessels from preexisting ones, are important processes during embryonic development, tissue growth, wound healing, and several pathological conditions. Several molecules are important for angiogenesis, most important being vascular endothelial growth factor (VEGF) family members and their corresponding receptors. VEGF belongs to the PDGF supergene family characterized by 8 conserved cysteines and functions as a homodimer structure. In mammals, the VEGF family consists o...
References:
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Structural determinants of growth factor binding and specificity by VEGF receptor 2.
Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2425-30. doi: 10.1073/pnas.0914318107. -
Vascular endothelial growth factor signaling pathways: therapeutic perspective.
Clin Cancer Res. 2006 Sep 1;12(17):5018-22. Review. -
Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies.
Genes Cancer. 2011 Dec;2(12):1097-105. doi: 10.1177/1947601911423031. -
Structure and function of VEGF receptors.
IUBMB Life. 2009 Sep;61(9):915-22. doi: 10.1002/iub.234. Review.
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