Pathways
Virus-Induced Airway Inflammation
Description:
More than 200 different types of viruses, such as human Rhinovirus (HRV), human Metapneumovirus (HMPV), Respiratory Syncytial Virus (RSV), and human Parainfluenza Virus (HPIV), are known to cause acute respiratory illness. Virus-induced cytokine production and inflammatory cell activation are instrumental in the development of neurogenic inflammatory responses, and these combined factors increase bronchoconstriction in response to allergens or irritants. Respiratory viruses primarily infect and re...
References:
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Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium.
Front Cell Dev Biol. 2020 Feb 25;8:99. doi: 10.3389/fcell.2020.00099. -
The airway epithelium: soldier in the fight against respiratory viruses.
Clin Microbiol Rev. 2011 Jan;24(1):210-29. doi: 10.1128/CMR.00014-10. -
Defining Bronchial Asthma with Phosphoinositide 3-Kinase Delta Activation: Towards Endotype-Driven Management.
Int J Mol Sci. 2019 Jul 18;20(14):3525. doi: 10.3390/ijms20143525. -
Rhinovirus replication and innate immunity in highly differentiated human airway epithelial cells.
Respir Res. 2019 Jul 12;20(1):150. doi: 10.1186/s12931-019-1120-0.
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