Pathways
Visual Cycle in Retinal Rods
Description:
The processing of visual information begins in the retina with the detection of light by photoreceptor cells. In humans, two types of photoreceptors in the retina mediate the light response: the rods which mediate vision in dim light and the cones which mediate bright light and color vision. Humans have one rod and three cones for long, medium- and short-waves. Rhodopsin is the photosensitive pigment of the rod photoreceptor cell that initiates the visual signaling cascade and is comprised of a pr...
References:
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11-cis- and all-trans-retinols can activate rod opsin: rational design of the visual cycle.
Biochemistry. 2008 Jul 15;47(28):7567-71. doi: 10.1021/bi800357b. Epub 2008 Jun 19. -
Retinal degeneration in animal models with a defective visual cycle.
Drug Discov Today Dis Models. 2013 Winter;10(4):e163-e172. doi: 10.1016/j.ddmod.2014.01.001. -
Photodynamic therapy for polypoidal choroidal vasculopathy.
Prog Retin Eye Res. 2013 Nov;37:182-99. doi: 10.1016/j.preteyeres.2013.09.003. -
GPCR Signaling Regulation: The Role of GRKs and Arrestins.
Front Pharmacol. 2019 Feb 19;10:125. doi: 10.3389/fphar.2019.00125.
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