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VPS34-PI3K Signaling in Saccharomyces cerevisiae


PI3Ks (Phosphoinositide-3 Kinases) are heterodimeric lipid kinases that are composed of a regulatory and catalytic subunit that are encoded by different genes (Ref.1). Two distinct VPS34P (Vacuolar Protein-Sorting-34-PI3K (Phosphatidylinositde-3 Kinase)) complexes occur in S. cerevisiae (Saccharomyces cerevisiae) in order to carry out autophagy and CpY (Carboxypeptidase-Y) sorting. VPS34P is activated by VPS15[...]




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