Pathways
VPS34-PI3K Signaling in Saccharomyces cerevisiae
Description:
PI3Ks (Phosphoinositide-3 Kinases) are heterodimeric lipid kinases that are composed of a regulatory and catalytic subunit that are encoded by different genes. The phosphorylated lipid phosphatidylinositol 3-phosphate (PtdIns3P) is an important signaling molecule and has been found to localize to endosomes, multivesicular bodies, phagosomes, midbodies, peroxisomes and omegasomes. The generated PtdIns3P attracts PtdIns3P-binding factors, which either contain a PX (Phox homology) domain or a FYVE (Fab1p, YOTB, Vac1p and EEA1) d...
References:
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The class III phosphatidylinositol 3-kinase Vps34 in Saccharomyces cerevisiae.
Biol Chem. 2017 May 1;398(5-6):677-685. doi: 10.1515/hsz-2016-0288. -
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity.
J Cell Biol. 2013 Oct 28;203(2):299-313. doi: 10.1083/jcb.201304123. -
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.
Science. 2015 Oct 9;350(6257):aac7365. doi: 10.1126/science.aac7365. -
Class III PI3K Vps34: essential roles in autophagy, endocytosis, and heart and liver function.
Ann N Y Acad Sci. 2013 Mar;1280:48-51. doi: 10.1111/nyas.12026.
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