Pathways
West Nile Virus Replication
Description:
WNV (West Nile Virus) is a single-stranded positive-polarity enveloped virus with icosahedral symmetry virus and the etiologic agent of West Nile encephalitis. It is a member of the Japanese encephalitis virus antigenic group within the family Flaviviridae, which can cause fatal encephalitis associated with damage to the CNS (Central Nervous System) in humans and animals. Wild birds are the natural reservoir (amplifying) hosts, and WNV transmission cycle primarily involving Culex sp mosquitoes. Initially isolated in...
References:
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West Nile Virus: An Update on Pathobiology, Epidemiology, Diagnostics, Control and "One Health" Implications.
Pathogens. 2020 Jul 19;9(7):589. doi: 10.3390/pathogens9070589. -
West Nile Virus Restriction in Mosquito and Human Cells: A Virus under Confinement.
Vaccines (Basel). 2020 May 29;8(2):256. doi: 10.3390/vaccines8020256. -
Interactions between the West Nile virus capsid protein and the host cell-encoded phosphatase inhibitor, I2PP2A
Cell Microbiol. 2007 Nov;9(11):2756-66. doi: 10.1111/j.1462-5822.2007.01046.x. Epub 2007 Sep 14. -
The Role of Host Cholesterol During Flavivirus Infection.
Front Cell Infect Microbiol. 2018 Nov 2;8:388. doi: 10.3389/fcimb.2018.00388.
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