Pathways
WNT Signaling in D. melanogaster
Description:
The Wg (wingless) pathway is highly conserved amongst various species and is important for embryonic development, including body axis patterning, cell fate specification, cell proliferation and cell migration. Additionally, Wnt signaling also controls tissue regeneration in adult bone marrow, skin and intestine.Much of our understanding of the role of Wnt proteins during development has come as a result of genetic analyses of the Drosophila Wg gene. In Drosophila, Wg is required during embryogenesis for segme...
References:
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Wnt/Wingless signaling in Drosophila.
Cold Spring Harb Perspect Biol. 2012 Jun 1;4(6):a007930. doi: 10.1101/cshperspect.a007930. -
Wg signaling in Drosophila heart development as a pioneering model.
J Genet Genomics. 2010 Sep;37(9):593-603. doi: 10.1016/S1673-8527(09)60079-5. -
The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies.
Curr Top Dev Biol. 2016;117:75-91. doi: 10.1016/bs.ctdb.2015.11.027. Epub 2016 Jan 7. -
Wingless/Wnt signaling in Drosophila: the pattern and the pathway.
Mol Reprod Dev. 2013 Nov;80(11):882-94. doi: 10.1002/mrd.22228. Epub 2013 Sep 18.
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