Pathways
WNT Signaling
Description:
WNT signaling pathways play essential roles in cellular proliferation, differentiation and cell migration during embryonic development. The importance of WNT signaling is indicated by conservation of its molecular components across organisms ranging from nematodes to humans. WNT pathways are classified into canonical WNT/CTNNB or non-canonical (β-catenin-independent) pathways. Canonical WNT/β- catenin signaling is the most studied, and is mediated by nuclear translocation of its central effector CTNNB and Non-canoni...
References:
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A growing field: The regulation of axonal regeneration by Wnt signaling.
Neural Regen Res. 2018 Jan; 13(1):43-52. doi: 10.4103/1673-5374.224359. Review. -
WNT signaling in glioblastoma and therapeutic opportunities
Lab Invest. 2016 Feb; 96(2):137-50. doi: 10.1038/labinvest.2015.140. Epub 2015 Dec 7. Review. -
Frizzled receptors signal through G proteins.
Cell Signal. 2013 Jun; 25(6):1468-75. doi: 10.1016/j.cellsig.2013.03.009. Epub 2013 Mar 19. -
Wnt signaling in cancer.
Oncogene. 2017 Mar; 36(11):1461-1473. doi: 10.1038/onc.2016.304. Epub 2016 Sep 12. Review.
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