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Pathways

ZIKA Virus Replication

Description:

Zika virus (ZIKV) is an arbovirus of the Flaviviridae family, which includes dengue, West Nile, yellow fever, and Japanese encephalitis viruses, that causes a mosquito-borne disease transmitted by the Aedes genus. Zika virus has emerged as a severe health threat by virtue of its fast paced global spread and its associated morbidities, including microcephaly and Guillain-Barre syndrome (Ref.1). ZIKV contains a positive, single-stranded genomic RNA encoding a polyprotein that is processed into three structural proteins, i.e., the ...

References:

  • The IFITMs Inhibit Zika Virus Replication.
    Savidis G, Perreira JM, Portmann JM, Meraner P, Guo Z, Green S, Brass AL.Cell Rep. 2016 Jun 14;15(11):2323-30. doi: 10.1016/j.celrep.2016.05.074. Epub 2016 Jun 3.
    Cell Rep. 2016 Jun 14;15(11):2323-30. doi: 10.1016/j.celrep.2016.05.074. Epub 2016 Jun 3.
  • Biology of Zika Virus Infection in Human Skin Cells.
    Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, Perera-Lecoin M, Surasombatpattana P, Talignani L, Thomas F, Cao-Lormeau VM, Choumet V, Briant L, Desprès P, Amara A, Yssel H, Missé D.
    J Virol. 2015 Sep;89(17):8880-96. doi: 10.1128/JVI.00354-15. Epub 2015 Jun 17.
  • Degrees of maturity: the complex structure and biology of flaviviruses.
    Pierson TC, Diamond MS.
    Curr Opin Virol. 2012 Apr;2(2):168-75. doi: 10.1016/j.coviro.2012.02.011. Epub 2012 Mar 23. Review.
  • Zika Virus: the Latest Newcomer.
    Saiz JC, Vázquez-Calvo Á, Blázquez AB, Merino-Ramos T, Escribano-Romero E, Martín-Acebes MA.
    Front Microbiol. 2016 Apr 19;7:496. doi: 10.3389/fmicb.2016.00496. eCollection 2016. Review.
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