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Featured Pathways

Displaying 313 to 324 (of 795 pathways)

Featured Pathways

DRPLA (Dentatorubropallidoluysian Atrophy) is a Rare Neurodegenerative Disorder that usually is inherited in an Autosomal Dominant pattern. The Clinical symptoms are variable depending on the age of onset of the disease Myoclonus, Epilepsy, and Mental Retardation are the main symptoms in Juvenile Onset, whereas Cerebellar Ataxia, Choreoathetosis, and Dementia are seen in Adult Onset.[..]

C. neoformans (Cryptococcus neoformans) is a Basidiomycetous fungus and a significant human pathogen with worldwide distribution. Its importance as an opportunistic pathogen has increased in the past two decades, largely as a result of AIDS (Acquired Immune Deficiency Syndrome), cancer chemotherapy and immuno-suppression for organ transplants. Infections begin in the lung[..]

U. maydis (Ustilago maydis) is a ubiquitous pathogen of corn. Pathogenesis, dimorphic growth and sexual development are intricately interconnected in the corn Smut fungus U. maydis, and the perception of signals from the host plant plays an important role in these processes. The life cycle of U. maydis is characterized by a dimorphic switch between a haploid[..]

cAMP (Cyclic Adenosine 3',5'-monophosphate) signaling regulates appressorium formation in the Rice Blast fungus M. grisea (Magnaporthe grisea). Both saprophytic and pathogenic growth of M. grisea is regulated by AC (Adenylate Cyclase)/Mac1 but different effectors of cAMP mediate downstream effects specific for either cell morphogenesis or pathogenesis. M.[..]

Atherosclerosis, the pathological basis of CAD (Coronary Artery Disease) and Ischemic Stroke, is the commonest cause of death and disability in the western world. Atherosclerosis is a multifactorial, highly complex disease with numerous aetiologies simultaneously and sequentially collaborating in subtle ways to affect lesion development, progression and maturation to an advanced,[..]

JAs (Jasmonates) are potent Lipid Regulators of Defense gene expression and act in development necessary for fertility. The Jasmonate Pathway performs critical roles in Plant Defense, Development, and Metabolism. Upon activation of plant immunity, several signaling events are initiated along with production of lipids and lipid related molecules including Phospholipids, sterols,[..]

The fission yeast S. pombe (Schizosaccharomyces pombe) is homothallic and has a defined sexual cycle involving mating between haploid cells of opposite mating types. In S. pombe, two signaling pathways coordinately regulate mating; the pheromone-activated MAPK (Mitogen-Activated Protein Kinase) signaling and nutrient-regulated, G-protein-cAMP (Cyclic Adenosine[..]

The ascomycete N. crassa (Neurospora crassa) has defined asexual and sexual cycles. N. crassa is heterothallic and has two mating types, A and a. Under nutrient-rich conditions like Carbon, etc, N. crassa proliferates by the extension and branching of multinucleate vegetative hyphal cells to form a multicellular mycelium (Ref.1). In response to nutrient[..]

All cells need to interpret their environment. Efficient processing of signals from the extracellular milieu is achieved through dynamic signal-transduction systems. The components of this system that come into contact first with external signals are cell-surface receptors. RTKs (Receptor Tyrosine Kinases) comprise one large group of receptors that respond to polypeptide growth factors and have[..]

Phagocytosis is an important process for nutrition in unicellular organisms, while in multicellular organisms it is found in specialized cells called phagocytes. Phagocytosis consists in recognition and ingestion of particles larger than 0.5 𝜇m into a plasma membrane derived vesicle, known as phagosome. Phagocytes can ingest microbial pathogens, but importantly also apoptotic cells. In[..]

Vitiligo is an acquired autoimmune skin disorder characterized by the destruction of skin melanocytes, resulting in the development of white patches. This disease can be psychologically devastating for the patients. It affects all races and occurs in 0.3–1.0% of the world population, and in 50% of cases the condition begins before the age of 20 years. More women than men are[..]

Plants respond to insect attack, defense against herbivory, and wound-healing by activating jasmonate family of signaling molecules. Jasmonic Acid (JAs) are plant hormones that regulate several physiological processes like defense responses to a variety of biotic and abiotic stresses, growth, development, fertility, and senescence. JAs can also[..]

Displaying 313 to 324 (of 795 pathways)


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