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Pathways

Featured Pathways

Displaying 145 to 156 (of 809 pathways)

Featured Pathways

Splicing of pre-mRNA (pre-mRNA) is a complex mechanism where introns are removed, and exons are joined together to form a mature mRNA competent for translation. Pre-mRNA splicing is tightly regulated and its failure is linked to various tumors, pathologies of the endocrine system and neurodegenerative disorders. The discovery that introns are removed during[..]

ATP Binding Cassette transporters comprise a large family of membrane-spanning proteins that are responsible for transporting a variety of substrates in prokaryotes and eukaryotes. The most intriguing and, arguably, the most important membrane proteins for this purpose are the ABC (ATP-Binding Cassette) transporters. These proteins, found in all species, use the energy of ATP hydrolysis to[..]

Biotin is a water-soluble vitamin found in all organisms that functions as a cofactor of Biotin-dependent carboxylases. It belongs to the B-Complex group of Vitamins and is an essential micronutrient for all mammals. The role of Biotin (or Vitamin-H) in Carboxylases is to act as vector for carboxyl-group transfer between donor and acceptor molecules during Carboxylation reaction (Ref.1).[..]

Biotin is a water-soluble Vitamin required by all organisms by virtue of its essential role in carboxylation reactions. Whereas animals lack the ability to synthesize Biotin, it is synthesized by microorganisms and plants and therefore is widespread in the food supply at low concentrations relative to most water-soluble Vitamins (Ref.1). The highest level of Biotin occurs in organ meats[..]

Herpesviridae is a large family of viruses including several members that are pathogenic to humans, causing a variety of disorders ranging from cold sores and chicken pox to less frequent conditions such as blindness and cancers. HSV1 (Herpes Simplex Virus Type-1), the prototypical member of this family, is a large DNA-containing neurotropic virus endemic in all human populations. Following[..]

Sterols are a structurally conserved class of lipids that play multifaceted roles in Eukaryotes, serving as essential components of Cell membranes and precursors to Steroid hormones. Characterized by a –OH group on the C3 of the Steroid nucleus, Sterols represent the most abundant type of Steroids in Vertebrates as well as in Plants. In Vertebrates, Cholesterol is by far the major[..]

Stmn1 (Stathmin-1) also referred to as Op18 (Oncoprotein-18) is a major regulator of microtubule dynamics. It is an evolutionarily well conserved 17 kDa cytoplasmic phosphoprotein that is highly expressed in a wide variety of cancers and its high abundance seems to be necessary for the maintenance of the transformed phenotypes. Breast cancers exhibit high levels of Stmn1 and may be resistant to[..]

The process by which the body prevents blood loss is referred to as coagulation. Thrombin/TFIIa (Activated Factor-II) is a multifunctional serine proteinase, which serves as an essential component of the process of Blood Coagulation - the hemostatic process of greatest interest. When a blood vessel is injured, bleeding is stopped by clotting (Coagulation) factors that form a thrombus (clot)[..]

Plant growth and development are regulated by Internal Signals and by External Environmental Conditions. One important regulator that coordinates growth and development with responses to the environment is the Sesquiterpenoid hormone ABA (Abscisic Acid). ABA plays important roles in many cellular processes including Seed Development, Dormancy, Germination, Vegetative Growth, Leaf Senescence,[..]

Methylococcus capsulatus is an obligate, Gram-negative methanotroph. It generally use the greenhouse gas Methane as a sole carbon and energy source for growth, thus playing major roles in global carbon cycles, and in particular, substantially reducing emissions of biologically generated Methane to the atmosphere. Methylococcus capsulatus is the first complete genome sequence reported[..]

Eukaryotic cells are characterized by extensive subcellular compartmentation whose structural basis is the existence of a number of highly specialized membrane-bound organelles. Each of these organelles is equipped with a specific subset of proteins allowing them to fulfill specific tasks in cellular metabolism. Mitochondria are present in virtually all eukaryotic cells. Mitochondria are the[..]

The Hh (Hedgehog) proteins are evolutionarily conserved signaling molecules that control the normal growth and patterning of diverse animals including Drosophila and humans. In flies, Hh is required for multiple developmental processes such as embryonic segment patterning, eye and appendage development. A single Drosophila Hedgehog gene has three mammalian counterparts:  SHh [..]

Displaying 145 to 156 (of 809 pathways)
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