Featured Pathways
One of the most interesting and perhaps best-studied plant bacterial interactions is between rhizobial species and economically important leguminous plants (soybean, alfalfa, beans, peas, etc.). Rhizobia are generally described as root-nodule-forming nitrogen-fixing symbionts belonging to one of five species, Rhizobium, Bradyrhizobium, Sinorhizobium,[..]
T. tengcongensis (Thermoanaerobacter tengcongensis) is a rod-shaped, Gram-negative, anaerobic eubacterium that metabolizes sugars as the principal source of energy and carbon source, and gains energy anaerobically by Sulfur respiration. T. tengcongensis has a complete collection of genes involved in most of the amino acid biosynthetic pathways for Threonine, Valine,[..]
The CD1 (Thymocyte Antigen CD1) antigen presentation system presents lipid and glycolipid antigens to effector T-Cells, which have diverse roles in Antimicrobial responses, Antitumor immunity and in regulating the balance between Tolerance and Autoimmunity. CD1, a conserved family of MHC (Major Histocompatibility Complex)-like glycoproteins in mammals, specializes in capturing lipid rather[..]
Hepatitis-C Virus (HCV) belongs to the Flaviviridae family and is the leading cause of chronic liver disease globally. It is estimated to infect about 170 million people around the world (WHO, 1997). Chronic HCV infection frequently leads to liver fibrosis and cirrhosis, and is associated with the occurrence of hepatocellular carcinoma. Acute infection occurs in only a few patients. In most[..]
B. melitensis (Brucella melitensis) is a Gram-negative, aerobic, facultative intracellular bacterial pathogen that causes abortion in goats and sheep and Malta fever in humans. Species in the genus Brucella are the etiological agents of Brucellosis, a zoonotic disease endemic in many areas of the world, characterized by chronic infections in animals leading to[..]
Species in the genus Brucella are the etiological agents of Brucellosis, a zoonotic disease endemic in many areas of the world, characterized by chronic infections in animals leading to abortion and infertility, and a systemic, febrile illness in humans. Brucella is facultative intracellular pathogens that enter the host through mucosal surfaces and are able to survive inside[..]
The GAs (Gibberellic Acids or Gibberellins) phytohormones play important roles in plant growth and development, promoting seed germination, elongation growth and reproductive development. GA is important for processes including seed germination, stem growth, and flower and fruit development. Gibberellins are modified in the endoplasmic reticulum and cytosol until they reach their[..]
Rhizobium, Bradyrhizobium, Mesorhizobium, Sinorhizobium, and Azorhizobium-collectively known as rhizobia, are Gram-negative, nitrogen-fixing bacteria of agronomic importance because they perform nitrogen-fixing symbioses with leguminous plants (soybean, alfalfa, beans, peas, etc). The metabolism of amino acids like Glycine is indispensable for[..]
R. baltica (Rhodopirellula baltica) is a marine, aerobic, heterotrophic representative of the globally distributed and environmentally important bacterial order Planctomycetales. They catalyze important transformations in global carbon and nitrogen cycles. From a phylogenetic perspective the order Planctomycetales forms an independent, monophyletic phylum of the domain[..]
Sterols are a structurally conserved class of lipids that play multifaceted roles in Eukaryotes, serving as essential components of Cell membranes and precursors to Steroid hormones. Characterized by a –OH group on the C3 of the Steroid nucleus, Sterols represent the most abundant type of Steroids in Vertebrates as well as in Plants. In Vertebrates, Cholesterol is by far the major[..]
Stmn1 (Stathmin-1) also referred to as Op18 (Oncoprotein-18) is a major regulator of microtubule dynamics. It is an evolutionarily well conserved 17 kDa cytoplasmic phosphoprotein that is highly expressed in a wide variety of cancers and its high abundance seems to be necessary for the maintenance of the transformed phenotypes. Breast cancers exhibit high levels of Stmn1 and may be resistant[..]
