• info@proteinlounge.com


Featured Pathways

Displaying 13 to 24 (of 825 pathways)

Featured Pathways

Drug addiction is considered as a chronic and relapsing psychiatric disorder induced by repeated pharmacological manipulation of mesolimbic reward circuitry during drugs of abuse. It is observe as maladaptive neural plasticity that occurs in vulnerable individuals in response to repeated exposure to drugs. Thus, addictive drugs change brain properties that normally permit us to adapt to[..]

GBS (Guillain-Barré Syndrome) is often known as post infectious, immune-mediated nerve injury. This syndrome results in inflammatory demyelination, characterized by acute weakness of the extremities and areflexia. The pathological features of GBS include inflammation, demyelination, and axonal damage in the PNS (Peripheral Nervous[..]

Coronavirus disease 2019 (COVID-19), the disease caused by the beta coronavirus SARS-CoV-2 was believed to be restricted to the respiratory system since its outbreak in January 2020. Later it was found that it also involves multiple other organs including the central and peripheral nervous system. Neurological problems like ischemic, hemorrhagic strokes, venous sinus thrombosis,[..]

Interleukin18 (IL18) is a pro-inflammatory IL-1 family cytokine that activates hematopoietic cell types involved in Th1 and Th2 responses. IL18 plays an essential role in the host defense against various infectious microorganisms. It also enhances the induction of IFN-gamma, nitric oxide (NO), and ROS in phagocytes. Expressed by both immune and non-immune cells like macrophages, keratinocytes,[..]

Human respiratory syncytial virus (RSV) is a spherical enveloped virus with a diameter of approximately 150 nm. It is filamentous, negative-sense, single-stranded RNA virus that belongs to the Orthopneumovirus genus of the Pneumoviridae family in the order Mononegavirales. The RNA genome consists of a non-segmented negative-sense single strand RNA along with 10 genes encoding 11 proteins. They[..]

Nipah virus (NiV), is a highly lethal zoonotic paramyxovirus that emerged at the end of last century as a human pathogen capable of causing severe acute respiratory infection and encephalitis.  NiV blocks the elicitation of innate and adaptive immune response by inhibiting synthesis of cytokines, interferon type I (IFN α/β) (Ref.1). The effects on humans of infection by Nipah[..]

COVID-19 is an infectious disease caused by a new coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has infected millions of people throughout the world leading to a global health crisis. COVID-19 declared as pandemic by World Health Organization, generally causes lung inflammation and pneumonia. In extreme cases, it can also cause injury to multiple organs[..]

Coronavirus disease 2019 (COVID-19) is a pandemic respiratory disease caused by a highly transmissible and pathogenic coronavirus, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which had an unusual outbreak in Wuhan, China, in December 2019. SARS-CoV-2, a novel beta-coronavirus, is characterized by a spherical morphology with spike projections on the surface. It shared high[..]

Statins are the most common drug used to treat hyperlipidemia. They also induce several pleiotropic effects like improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory responses, and stabilization of atherosclerotic plaques. The different pleiotropic effects arise due to marked differences in lipophilicity, solubility[..]

Immune checkpoints are co-stimulatory or inhibitory molecules that serve as regulators of T cells function in the tumor microenvironment. Inhibitory immune checkpoints maintain immune homeostasis, down-regulate anti-tumor responses and prevent autoimmunity (Ref.1). Checkpoint pathways involve costimulatory and inhibitory receptors and their ligands. Costimulatory receptors[..]

Chemokines are chemotactic cytokines belonging to a large family of small, secreted proteins that stimulate the cells migration and the positioning and interactions of cells within tissue. About 50 endogeneous chemokine ligands and 20 cell surface G protein-coupled heptahelicalchemokine receptors together form the chemokine superfamily. Chemokines regulate leukocyte migration into the tumor[..]

Cholesterol is the key component of the structure and function of cell membranes and is biosynthesized by all animal cells. Cholesterol biosynthesis occurs in the liver and the intestines. The liver has two sources of cholesterol either it can take up LDL particles from the blood, or it can synthesis cholesterol using HMG-CoA reductase adding to the cholesterol pool in[..]

Displaying 13 to 24 (of 825 pathways)


9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA

Tel: 858-224-2869
Fax: 858-205-1192

Institutional License

Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.

To set up a license, please contact: info@proteinlounge.com

Copyright © Protein Lounge Inc.
   Terms & Conditions